Life Extension Benfotiamine with Thiamine (100 mg) -- 120 Vegetarian Capsules

Benfotiamine is a fat-soluble form of vitamin B1 (thiamine) which helps to support healthy blood sugar metabolism and protect your body’s tissue from advanced glycation end products and oxidative stress. For example, the enzyme transketolase is critical to blood sugar metabolism. Like many enzymes, transketolase requires a co-factor. In this case, it needs assistance from thiamine. Unfortunately, thiamine is water-soluble, which makes it less available to the interior of the cell. Benfotiamine is fat-soluble and can easily penetrate into the inside of cells. It is also more bioavailable than the water-soluble thiamine.

Benfotiamine can activate glucose metabolism and promote healthy blood glucose levels in those already within normal range. Benfotiamine can also reduce the formation of advanced glycation end products to help prevent glucose toxicity and correct endothelial cell defects which are caused by high concentrations of blood , especially inside endothelial, retinal, kidney and nerve cells. Benfotiamine also helps maintain healthy endothelial function. Life Extension Benfotiamine with Thiamine is an inexpensive dietary supplement which can assist in maintaining blood sugar levels in those already within normal range. It will also help to support the health of the nerves, kidneys, eyes, blood vessels, and heart.

In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage. Benfotiamine also blocks the activation of the transcription factor known as nuclear factor-kappa B (NF-kB), which is implicated in numerous inflammatory conditions.